1969: Normal people's production of hydrogen (hydrogen)
Using the technique of enteral gas infusion, the hydrogen production in the human intestine was studied. The volume of H2 in the intestines of 10 normal people ranged from 0.06 to 29ml. H2 production averaged 0.24ml per minute in the fasted state and increased dramatically to 1.6ml per minute when lactose was instilled in the intestines. Digestion of food stimulates a seven-fold to thirty-fold increase in H2 production. In a normal gut, more than 99% of H2 is produced by the colon, but in people with high numbers of small intestinal bacteria, H2 is produced by the small intestine. H2 in the human body is produced by digested food and intestinal bacteria.
1975: Effect of Hydrogen on Skin Tumors (Anticancer Effect)
M Dole, FR Wilson Tests with hydrogen gas in hairless albino mice with squamous cell carcinoma. Mice were exposed to 2.5% oxygen and 97.5% hydrogen at a total pressure of 8 atmospheres for 2 weeks to observe whether free radicals in antioxidants such as hydrogen would cause the regression of skin tumors. It was found that the tumor had an obvious recovery state, so it proved that high-pressure hydrogen has the possibility of treating cancer.
2001: Anti-inflammatory effect of hydrogen on hepatitis
When hydrogen reacts with hydroxyl radicals to produce highly cytotoxic substances in inflamed tissues, it is speculated that hydrogen has an anti-inflammatory effect. It has therefore been proposed to use gaseous hydrogen as a new therapy in the anti-inflammatory field.Gharib B1, Hanna S, Abdallahi OM, Lepidi H, Gardette B., De Reggi MThe idea was tested using the equipment and technology of COMEX SA in Marseille, using a mixture of oxygen and hydrogen in professional deep-sea diving equipment as the inhalation gas for experiments. Schistosoma japonicum patients with chronic hepatitis were used as test subjects. Infected animals in a hyperbaric chamber with normal atmospheric concentration plus 0.7MPa hydrogen for two weeks were found to have a significant protective effect on liver disease, that is, reduced fibrosis, improved hemodynamics, increased NOSII activity, and antioxidant enzyme activity increased, decreased lipid peroxide levels and decreased circulating TNF-α levels. Under the same conditions, helium also played a protective role, indicating that hydroxyl radical scavenging is not the only protective mechanism. These findings suggest that the proposed anti-inflammatory strategy deserves further attention.
2007: The role of hydrogen is to selectively remove free radicals
Acute oxidative stress caused by ischemia-reperfusion or inflammation causes severe damage to tissues, and persistent oxidative stress is recognized as one of the causes of many common diseases including cancer. We show here that hydrogen (H(2)) has potential as an antioxidant for preventive and therapeutic applications. We induced acute oxidative stress in cultured cells by three independent methods. H(2) selectively reduces hydroxyl radicals, the most cytotoxic reactive oxygen species (ROS), and effectively protects cells; however, H(2) does not react with other ROS with physiological effects. Using an acute rat model, we induced oxidative stress injury in the brain by ischemia and reperfusion. Inhalation of H(2) gas alleviated the effects of oxidative stress significantly inhibited brain injury. H(2) can thus be used as an effective antioxidant therapy; due to its ability to rapidly diffuse across membranes, it can react with cytotoxic ROS, thereby preventing oxidative damage.
2008: High-concentration hydrogen water improves lipid and glucose metabolism in diabetics
Oxidation has been widely implicated in various diseases, including diabetes, hypertension and atherosclerosis. Hydrogen is recognized to have a reducing effect. Therefore, a randomized, double-blind, placebo-controlled, cross-over study was conducted on patients with diabetes mellitus and impaired glucose tolerance using hydrogen-containing water. Conclusions suggest that hydrogen-containing water may be beneficial in the prevention of diabetes mellitus (T2DM) and insulin resistance.
2008: High-concentration hydrogen water prevents brain peroxide formation
Hydrogen is a well known antioxidant. In order to clarify the role of hydrogen in the brain, we used three groups of mice to test the antioxidant effects of hydrogen, vitamin C and water on the brain for 33 days. Superoxide formation in brain slices from these groups during hypoxia-reoxygenation treatment was estimated by a real-time conduction imaging system that models living brain tissue using Lucigenin as a chemiluminescence probe for superoxide. Needle. The formation of superoxide after ischemia-reperfusion in the H(2) group was significantly reduced by 27.2% compared with the H(2)O group. Therefore, hydrogen-enriched pure water acts as an antioxidant and prevents superoxide formation in brain slices.
2010: The antioxidant effect of high-concentration hydrogen water on subjects with potential metabolic syndrome
In this study, we demonstrated that drinking high-concentration hydrogen water increased the urinary antioxidant enzyme SOD, an endogenous defense system that inhibits ROS-induced cell damage and reduces oxidative stress markers in patients with metabolic syndrome.
2012: Effect of high-concentration hydrogen water on muscle fatigue induced by strenuous exercise in elite athletes
Adequate hydration, as well as the high concentration of hydrogen in the water, can reduce blood lactate levels in elite athletes and improve the decline in muscle function caused by strenuous exercise. While further research clarification needs to be confirmed in a larger series of studies, these preliminary results may suggest that high concentrations of hydrogen water may be suitable for athletes to hydrate.
2013: Hydrogen inhibits bone cell damage induced by TNFα
(Positive effect on rheumatoid arthritis and osteoporosis)
Tumor necrosis factor-α (TNFα) is strongly involved in inflammatory diseases such as rheumatoid arthritis and postmenopausal osteoporosis. Hydrogen, a novel antioxidant, has recently been shown to exert therapeutic anti-inflammatory effects in many diseases. In the present study, we investigated the effect of molecular hydrogen (H(2)) on TNFα-induced osteoblast injury. Osteoblasts isolated from neonatal rats were cultured for experiments. TNFα was found to inhibit cell viability, induce apoptosis, inhibit Runx2 mRNA expression, and inhibit alkaline phosphatase activity, while H(2) could reverse TNFα. Cultured TNFα-enhanced intracellular reactive oxygen species (ROS) formation and malondialdehyde production increased NADPH oxidase activity, impaired mitochondrial function, increased mitochondrial ROS generation, decreased mitochondrial membrane potential and ATP synthesis, and inhibited SOD and excess Antioxidant enzyme activities such as catalase were restored by co-incubation with H(2). Treatment with H(2) inhibits TNFα-induced activation of the NFκB pathway. Furthermore, treatment with H(2) suppressed TNFα-induced nitric oxide (NO) formation by inhibiting iNOS activity. Treatment with H(2) inhibited TNFα-induced IL-6 and ICAM-1 mRNA expression. In conclusion, H(2) treatment attenuated TNFα-induced osteoblast injury by alleviating oxidative stress, protecting mitochondrial function, inhibiting inflammatory response, and increasing nitric oxide bioavailability.
2018: Hydrogen as a potential treatment for lung cancer
Hydrogen can inhibit the viability, migration and invasion of A549 and H1975 cells, promote cell apoptosis, and induce cell G2/M phase arrest. Animal experiments found that inhalation of 60% hydrogen can inhibit tumor growth, but the effect is not as good as cisplatin. Immunohistochemical staining showed that the changes of Ki-67, VEGF and SMC3 were also consistent with the above changes.
